Robert borgon vinculin thesis

Stuff i dont remember white and borgon ucf learn with flashcards, games, and more — for free. Vinculin associates with a large number of cytoskeletal and signaling proteins, and this flexibility is thought to contribute to rapid dissociation and reassociations of adhesion complexes robert a borgon affiliations department of hematology-oncology, st jude children's research hospital, 332 n lauderdale street, memphis, tn 38105 usa. Contact dr robert borgon for more details it would also help to think outside the box and explore off-campus opportunities research and training opportunities in the orlando area include. A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions we thank dr eileen adamson for the vinculin null cells, drs robert johnson and pierre coulombe for comments on the manuscript, and begum dilshad choudhury for excellent technical assistance borgon, r a, vonrhein, c.

Others will study neurosciences, biotech professional sciences and a biomedical non-thesis track the group is diverse in many ways they represent 16 countries including brazil, bangladesh, india, jordan, jamaica and lithuania and will work on a range of research topics. @misc{borgon04structuraldynamics, author = {robert a borgon and clemens vonrhein and tina izard and robert a borgon and clemens vonrhein and tina izard}, title = {structural dynamics of -actinin–vinculin}, year = {2004. My thesis work focused on evaluating an antibiotic drug called rhb 104 against the pathogenic mycobacterium avium paratuberculosis (map), which has been linked to crohn's disease. This triggers vinculin to partly unravel as well, freeing several molecular fingers that assume a shape that allows alpha-actinin to bind to its partner other authors include robert a borgon (st jude) and clemens vonrhein (global phasing limited, cambridge, uk.

7 ways make your home more eco friendly by josh story february 5, 2016 architect or building designer: who do i need. Xiao peng, a 2011 phd with kris demali, has been named the winner of the 2012 clarence berg awardthis prize is given every other year to a student who demonstrates “scholarship, integrity, cooperativeness, consideration and a willingness to help others. Abstract αe-catenin, an essential component of the adherens junction, interacts with the classical cadherin–β-catenin complex and with f-actin, but its precise role is unknown αe-catenin also binds to the f-actin-binding protein vinculin, which also appears to be important in junction assembly. View robert pope’s profile on linkedin, the world's largest professional community robert has 9 jobs listed on their profile see the complete profile on linkedin and discover robert’s. Crystal structure of human vinculin author links open overlay panel robert a borgon 1 2 clemens vonrhein 3 gerard bricogne 3 philippe rj bois 4 tina izard 1 show more in the actin cytoskeleton following the formation of cell-matrix and cell-cell junctions are orchestrated by vinculin vinculin associates with a large number of.

Other authors include robert a borgon (st jude) and clemens vonrhein (global phasing limited, cambridge, uk) this work was supported in part by the national institutes of health, a cancer. All print theses and dissertations are available at the university of iowa libraries please search our catalog you can add the word “thesis” to your search to help narrow your search. Vinculin and the heart: lessons from genetically manipulated mouse models while homozygous global inactivation of the murine vcl gene caused embryonic lethality ( 54 ) with embryos displaying a thin-walled myocardium, hemizygous ko mice (vcl +/− ) developed normally and were indistinguishable from wild type (vcl +/+ . About dr robert borgon i teach quantitative biological methods (bsc 3403), molecular biology i (pcb 3522), and peer instruction and laboratory occupational training (pilot, pcb 4943) my prior research focused on determining the molecular structure, activation, and interactions of proteins involved in cell adhesion.

robert borgon vinculin thesis Results from double labeling of pkcα and vinculin/talin under relaxed condition or cpi-17 and vinculin/talin under stimulated condition suggested that pkcα and cpi-17 were not associated with the adherens junction.

Central florida (ucf) - microbiology (mcb) professor ratings and course reviews. Vinculin and its splice variant, metavinculin (mv), are key elements of multiple protein assemblies linking the extracellular matrix to the actin cytoskeleton vinculin is expressed ubiquitously, whereas mv is mainly expressed in smooth and cardiac muscle tissue the only difference in amino acid sequence between the isoforms is a 68-residue insert in the c-terminal tail domain of mv (mvt. The role of npm-alk signaling in tumor cell metabolism by scott robert paul mcdonnell a dissertation submitted in partial fulfillment of the requirements for the degree of doctor of philosophy acknowledge my thesis committee members (dr lucas, dr cho, dr donato, dr. Abstract vinculin regulates both cell-cell and cell-matrix junctions and anchors adhesion complexes to the actin cytoskeleton through its interactions with the vinculin binding sites of α-actinin or talin.

Thesis chair: robert borgon, phd ii abstract postural orthostatic tachycardia syndrome (pots) is a common yet frequently misdiagnosed dysautonomia characterized by a significant increase in heart rate upon standing pots patients experience severe fatigue, dizziness, pre-syncope, and a. Abstract although extracellular matrix (ecm) stiffness is an important aspect of the extracellular microenvironment and is known to direct the lineage specification of stem cells and affect cancer progression, the molecular mechanisms that sense ecm stiffness have not yet been elucidated.

Robert a borgon, clemens vonrhein, and tina izard, which was published in molecular and cellular biology (mcb), vol 25, no 14, july 2005, pages 6112- 22 (corrected august 2007. From the following article: vinculin activation by talin through helical bundle conversion tina izard, gwyndaf evans, robert a borgon, christina l rush, gerard bricogne and philippe r j bois. Robert borgon and christina rush, pub- vinculin in the jan 8 edition of the jour-nal nature vinculin is an essential regulator of both cell-cell and cell-matrix interactions vinculin also plays a critical role in can- the university of tennessee health science center c 15 2004 27.

robert borgon vinculin thesis Results from double labeling of pkcα and vinculin/talin under relaxed condition or cpi-17 and vinculin/talin under stimulated condition suggested that pkcα and cpi-17 were not associated with the adherens junction.
Robert borgon vinculin thesis
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